Program

Wednesday 19th of September 2012 

16:00-17:00

Registration, Holmenkollen Park Hotel, Oslo

17:00-17:05

Welcome by Tone Tønjum and Lene Juel Rasmussen

17:05-17:10

Keynote speaker 1: Intro by Vilhelm A.  Bohr

17:10-18:00

Douglas Wallace, Children's Hospital of Philadelphia and University of Pennsylvania, US: A Mitochondrial Etiology of Complex Diseases: Verification through Mouse Models

18:00-18:10

Address from the Rector: Ole Petter Ottersen, University of Oslo, Norway: On Neuroscience, Genome Maintenance and Society

18:10-18:15

Keynote speaker 2: intro by Ole Petter Ottersen

18:15-19:05

Karl Deisseroth, Stanford University, US:  Optogenetics: Development and Application

19:05

Reception dinner at Holmenkollen Park Hotell

Thursday 20th of September 2012

Session 1: DNA damage responses – ATM

09:00-09:05

Chair intro: Cynthia McMurray

09:05-09:25

Yossi Shiloh, Tel Aviv University, Israel: On the Neurological Phenotype of Ataxia-Telangiectasia

09:25-09:45

Peter McKinnon, St Jude Children's hospital, US: Deciphering Ataxia Telangiectasia: ATM Signaling and the Response to DNA Damage in the Nervous System

09:45-10:05

Karl Herrup, Hong Kong University of Science and Technology, Hong Kong: The Impact of ATM Function on the Epigenome: New Insights into the Mechanisms of Neurodegeneration in A-T

10:05-10:30

Coffee break

10:30-10:50

Ari Barzilai, Tel-Aviv University, Israel: The Role of Malfunctioning DNA Damage Response (DDR) on Brain Functionality

10:50-11:10

Zhao-Qi Wang, Leibniz Institute for Age Research, Germany: Early DNA Damage Response in Neuropathology

11:10-11:30

 Philip Hastings, Baylor College of Medicine, US: Mechanisms of Change in Gene Copy Number

11:30-12:30

Lunch

Session 2: Bioenergetics I:  Consequences of mitochondrial dysfunction

12:30-12:35

Chair intro: Yossi Shiloh

12:35-12:55

Lene Juel Rasmussen, University of Copenhagen, Denmark: Impact of Mitochondrial Function on Genomic Stability

12:55-13:15

Keshav Singh, University of Alabama at Birmingham, US: Genomic Insights into Warburg Effect and its Role in Cancer

13:15-13:35

Lars Eide, University of Oslo, Norway: Brain Cell-Specific Effects of Mitochondrial DNA Damage and Repair

13:35-13:55

Jens Pahnke, University of Magdeburg, Germany: Effects of ATP-Dependent Transport Processes in Neurodegenerative Diseases - New Ways of Diagnostics and Treatment?

13:55-14:25

Coffee break

Session 3: Bioenergetics II:  Mitochondrial function and maintenance of mitochondrial genome

14:25-14:30

Chair intro: Lene Juel Rasmussen

14:30-14:50

Vilhelm A. Bohr, National Institute on Aging, US: Mitochondrial Genome Integrity and Neurodegeneration

14:50-15:10

Tinna V. Stevnsner, University of Århus, Denmark: Protein Interactions for Cockayne Syndrome Group B (CSB) Protein in Base Excission Repair (BER)

15:10-15:30

David Nicholls, Buck Institute for Research on Aging, US: Bioenergetic Function in Neuronal Cells

15:30-17:00

Excursion: Holmenkollen Ski Jump and Ski Museum, Tower and viewpoints 

17:00-18:30

Poster sessions

19:00

Dinner at Holmenkollen Park Hotell

Friday 21st of September 2012

Session 4: DNA repair I - Basic mechanisms of DNA repair and epigenetics

09:00-09:05

Chair intro: Vilhelm A. Bohr

09:05-09:25

Cynthia McMurray, Lawrence Berkeley National Laboratory, US: Bases for Region-Specific Toxicity and Genome Instability in Huntington's Disease Brain

09:25-09:45

Arne Klungland, University of Oslo and Oslo University Hospital, Norway: Alkbh1-9; roles in DNA repair and beyond

09:45-10:05

David Wilson III, National Institute on Aging, US: Functions of the Cockayne Syndrome Proteins

10:05-10:30

Coffee break

10:30-10:50

Hans Krokan, Norwegian University of Science and Technology, Norway: Sources and Processing of Genomic Uracil in Mammalian Cells

10:50-11:10

Pål Falnes, University of Oslo, Norway: Repair and Modification of Nucleid Acids by AlkB Proteins

11:10-11:25

Young Investigator Presentation: Peter Sykora, National Institute on Aging, US: The Neurological Consequences of Pol Beta Dysregulation in an Alzheimer's Mouse Model

11:25-12:30

Lunch

Session 5: DNA repair II DNA repair defects and human disease

12:30-12:35

Chair intro: Arne Klungland

12:35-12:55

 Jan Vijg, Albert Einstein College of Medicine, US: Single Cell Genomics and Epigenomics 

12:55-13:15

Magnar Bjørås, CMBN, Oslo University Hospital, Norway: Maintenance of Brain Function by Neil Dependent Repair of Oxidative DNA Damage

13:15-13:35

Linda Hildegard Bergersen, University of Oslo and Oslo University Hospital: Mitochondrial DNA Damage in Hippocampus 

 13:35-14:05

Coffee Break

14:05-14:25

Hilde Nilsen, University of Oslo, Norway: The Base Excision Repair Enzyme NTH-1 is Required for Transcriptomic and Proteomic Reprogramming in a C. elegans xpa-1 Nucleotide Excision Repair Mutant

14:25-14:45

Yousin Suh, Albert Einstein College of Medicine, US: Genome Maintenance, Aging, and Longevity in Humans

14:45-15:05

Jean-Marc Egly, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France: Transcription Activation Complex Disruption and Neurological Problems

15:05-16:45

Poster session

17:00

Bus departure to the city

18:00

Reception at the Oslo City Hall

19:30

Leisure time in Oslo city 

Saturday 22nd of September 2012

Session 6: DNA damage responses III- Cell fate decision

09:00-09:05

Chair intro: Magnar Bjørås

09:05-09:25

Keith Caldecott, University of Sussex, UK: DNA Strand Breaks and Neurodegenerative Disease

09:25-09:45

Domenico Delia, University of Milan, Italy: Neurological Differentiation and DNA Repair Capacity of ATM-Deficient Human Neural Stem Cells and A-T Patient Derived iPS Cells

09:45-10:05

Ian D. Hickson, University of Copenhagen, Denmark: RecQ Helicases: Suppressors of Cancer and Premature Aging

10:05-10:30

Coffee break

Session 7: Genome dynamics in infection biology

10:30-10:35

Chair intro: Peter McKinnon

10:35-10:55

Tone Tønjum, Oslo University Hospital and University of Oslo, Norway: Genome Instability in Meningitis Pathogens

10:55-11:15

Mike Koomey, University of Oslo, Norway: Genome Dynamics Governing Glycan Diversification in a Bacterial Model System

11:15-11:35

Umesh Varshney, Indian Institute of Science, Bangalore, India: DNA Repair in Mycobacteria

11:35-12:30

Lunch

12:30-12:50

Susan Rosenberg, Baylor College of Medicine, US: Mutation as a Stress Response and the Regulation of Evolvability

Session 8: Aging - Neurodegeneration and Alzheimer's disease

12:50-12:55

Chair intro: Linda H. Bergersen

12:55-13:15

Mark A. Lovell, University of Kentucky, US: DNA Modification in the Progression of Alzheimer's Disease

13:15-13:35

Martin Lauritzen, University of Copenhagen, Denmark: Local Control of Brain Oxygen Consumption in Relation to Activity in Neurons and Astrocytes, and Changes with Age

 Session 9: Young investigator presentations

 13:35-13:40

Chair Intro: Ole Herman Ambur and Claus Desler

13:40-13:55

Young Investigator I:  Sherif El-Khamisy, University of Sussex, UK: Breaking and Sealing One Strand of DNA: A role for SUMO

 13:55-14:10

 Young Investigator II: Yngve Sejersted, University of Oslo, Norway: NEIL2 Deficiency Reduces Hypoxic-Ischemic Brain Injury

14:10-14:50

Coffee break - Poster sessions

Session 10: Aging - neurodegeneration and alzheimer's disease II

14:50-14:55

Chair intro: Keith Caldecott

14:55-15-15

Martin Lavin, University of Queensland, Australia: Ataxia Oculomotor Apraxia type 2 : How Senataxin Functions to Maintain Genome Stability

15:15-15:35

George Martin, University of Washington, Seattle, US: Stochastic Variations of Gene Expression and the Pathogenesis of Geriatric Pathologies

15:35-15:50

Coffee Break

15:50-16:35

Panel Discussion

16:35-16:40

Keynote speaker 3: Intro by Reidun Torp

16:40-17:20

Gerard D.  Schellenberg, University of Pennsylvania School of Medicine, US: Neurodegenerative Disease Genetics; GWAS, Exomes and Beyond

17:00-17:20

Closing remarks by Tone Tønjum and Lene Juel Rasmussen

18:00

Bus to the Norwegian Technical Museum (NTM)

18:30 

Dinner and exhibition ”MindGap” at NTM

Sunday 23rd of September 2012

Departure